Berberine Hydrochloride-loaded Liposomes Gel: Preparation, Characterization and Antioxidant Activity

Abstract: Aim: Berberine hydrochloride is a Traditional Chinese Medicine component with antibacterial, antiviral, anti-inflammatory, antioxidant and lowering blood sugar effects. However, the application of berberine has been hindered for long time due to its poor solubility low bioavailability. This study aims design liposomes-gel enhance bioavailability activity hydrochloride. Materials Methods: The thin-film dispersion hydration method was used prepare liposomes, prepared by natural swelling using sodium alginate as hydrogel matrix. hydrochloride-loaded characterized encapsulation efficiency, particle size, potential, transmission electron microscopy, studied in vitro release preparations. Results: results revealed efficiency liposomes 79.62±4.20% mean size 153.7±11.2 nm. from conformed first-order model. scavenging rate DPPH free radicals H2O2 exceeds 70%. Conclusion: sustained-release effect on hin vitroad good properties measuring ability radicals, lipid peroxidation resistance. Keywords: hydrochloride, Liposomes, Sodium alginate, Hydrogel, Antioxidant.